Investigating the Frequency and Outcome of Central Vein Sign and Paramagnetic Rim Lesions in Children With MOGAD
Lesion pathobiology in MOGAD is heterogeneous. CVS identified persistent rather than transient lesions, with resolution more common among CVS- lesions. The high frequency of confluent or multivein lesions limited the proportion suitable for CVS analysis. MRI timing influenced CVS detection, which was higher in remission, suggesting that time of acquisition contributes to variability across MOGAD studies. No PRLs were found, supporting their potential as biomarkers distinguishing MOGAD from MS.
Authors
- Simone Sacco (ORCID: https://orcid.org/0000-0001-8789-3099)
- Sniya Sudhakar (ORCID: https://orcid.org/0000-0002-7632-9705)
- Akash Virupakshaiah (ORCID: https://orcid.org/0000-0003-2624-9974)
- Laura Cacciaguerra (ORCID: https://orcid.org/0000-0001-9342-2410)
- Hadas Meirson (ORCID: https://orcid.org/0000-0002-1836-5679)
- Asthik Biswas
- Ermelinda De Meo (ORCID: https://orcid.org/0000-0001-5531-1111)
- S J Pittock
- Roland Henry
- Dr Thomas Rossor
- Riccardo Nistri (ORCID: https://orcid.org/0000-0002-5479-8201)
- Dr Yael Hacohen
- Olga Ciccarelli
- Cheryl Hemingway
- John J. Chen
- Li-tal Pratt
- Emmanuelle Waubant
- Liat Bensira
- Nico Papinutto
- Evangeline Wassmer
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Tel Aviv University (IL)
- Queen Mary University of London (GB)
- University of California, San Francisco (US)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Tel Aviv Sourasky Medical Center (IL)
- Great Ormond Street Hospital (GB)
- Birmingham Children's Hospital (GB)
- Mayo Clinic in Arizona (US)
- UCL Biomedical Research Centre (GB)
- Mayo Clinic in Florida (US)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neurology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1212/wnl.0000000000214410
- Citations
- 1
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 39.15