Paraneoplastic neurological syndrome with Guillain–Barré syndrome overlap in small-cell lung carcinoma: A case report from a primary care hospital in China

For patients with subacute neuropathy and unexplained weight loss in primary care settings, routine paraneoplastic antibody testing and whole-body imaging (e.g., positron emission tomography-computed tomography) are essential to facilitate early recognition of PNS-GBS overlap syndromes. Multidisciplinary collaboration across neurology, oncology, and radiology is key to timely management and improved prognosis in resource-limited healthcare environments, even in the absence of classic disease phenotypes.

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Publication Details

Journal
Medicine
Published
2026-01-09
DOI
https://doi.org/10.1097/md.0000000000047045
Primary Topic
Peripheral Neuropathies and Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Paraneoplastic neurological syndrome with Guillain–Barré syndrome overlap in small-cell lung carcinoma: A case report from a primary care hospital in China

Z Zhang, Xin Li, Deling Zhong
Medicine
Peripheral Neuropathies and Disorders
article

Paraneoplastic neurological syndrome with Guillain–Barré syndrome overlap in small-cell lung carcinoma: A case report from a primary care hospital in China

Z Zhang, Xin Li, Deling Zhong
article en

Abstract

For patients with subacute neuropathy and unexplained weight loss in primary care settings, routine paraneoplastic antibody testing and whole-body imaging (e.g., positron emission tomography-computed tomography) are essential to facilitate early recognition of PNS-GBS overlap syndromes. Multidisciplinary collaboration across neurology, oncology, and radiology is key to timely management and improved prognosis in resource-limited healthcare environments, even in the absence of classic disease phenotypes.

MedicineVol. 105(2)
Zhejiang Chinese Medical University (CN), Hangzhou Hospital of Traditional Chinese Medicine (CN)
Openalex Percentile: Top 91%
Peripheral Neuropathies and Disorders
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