Cerebrovascular disease and neuroinflammation predict change in Alzheimer's disease plasma biomarkers in adults with Down Syndrome

Cerebrovascular lesions promote astrocyte-related inflammation, particularly in the context of elevated amyloid pathology, which has a downstream effect on tau pathophysiology in adults with DS. The results support the hypothesis that the interface between CVD and astrocytosis is critical in AD progression in people with DS.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105529
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Cerebrovascular disease and neuroinflammation predict change in Alzheimer's disease plasma biomarkers in adults with Down Syndrome

Juyoung Hahm, Mohamad J. Alshikho, Adam Brickman, Donna M. Wilcock et al.
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Cerebrovascular disease and neuroinflammation predict change in Alzheimer's disease plasma biomarkers in adults with Down Syndrome

Juyoung Hahm, Mohamad J. Alshikho, Adam Brickman, Donna M. Wilcock, Sid E. O'Bryant, Jose Gutierrez, Patrick J. Lao, Batool M. Rizvi, Lisi Flores‐Aguilar, Elizabeth Head, Natalie C. Edwards, Melissa Petersen
article en

Abstract

Cerebrovascular lesions promote astrocyte-related inflammation, particularly in the context of elevated amyloid pathology, which has a downstream effect on tau pathophysiology in adults with DS. The results support the hypothesis that the interface between CVD and astrocytosis is critical in AD progression in people with DS.

Alzheimer s & DementiaVol. 21(S2)
University of North Texas (US), NewYork–Presbyterian Hospital (US), University of North Texas Health Science Center (US), University of Pittsburgh (US), University of California, Irvine (US), New York Hospital Queens (US), Institute on Aging (US), Indiana University – Purdue University Indianapolis (US), Columbia University (US), University of California, Davis (US)
Good health and well-being
Openalex Percentile: Top 24%
Down syndrome and intellectual disability research
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