Imaging‐based biological staging associates with brain atrophy in preclinical Alzheimer's disease
Our findings reveal that the imaging-based biological AD staging is closely associated with cortical brain atrophy, showing a gradual acceleration in rates of cortical atrophy across stages. Additionally, our results suggest that serial volumetric measurements of temporoparietal brain regions may be sensitive biomarkers of early disease progression. Taken together, our findings provide valuable insights for applying the imaging-based biological AD staging in preclinical AD.
Authors
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Nesrine Rahmouni
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Andrei Bieger (ORCID: https://orcid.org/0000-0002-6669-2834)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Anderson Silva Corin (ORCID: https://orcid.org/0009-0004-1148-7085)
- Isabela Just de Jesus Vanni
- Pamela C.L. Ferreira
- João Pedro Ferrari‐Souza
- Arthur Macedo
- Eduardo R. Zimmer
- Joseph Therriault
- Lorenzo Fontura Brasil Barcellos
- Bruna Bellaver
- Marco Antônio Albini Valer
- Giovanna Carello‐Collar
- Diogo O. Souza
- Guilherme Povala
- Wyllians Vendramini Borelli
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- University of Pittsburgh (US)
- Hospital São Lucas da PUCRS (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107663
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00