Impaired CSF Clearance Contributes to the Retention of Alzheimer's Biomarkers Independent of Blood‐Brain Barrier Dysfunction
Our results support the concept that impaired CSF clearance contributes to the accumulation of AD biomarkers in the CNS. Moreover, the impaired CSF clearance does not seem to be associated with BBB dysfunction. These results highlight CSF clearance as a potential therapeutic target for AD, emphasizing the need to explore mechanisms that enhance peptide drainage from the CNS.
Authors
- Chris Hsiao (ORCID: https://orcid.org/0009-0009-2062-3516)
- Nesrine Rahmouni
- Wan Lu Jia
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Yansheng Zheng
- Yi‐Ting Wang
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Arthur Macedo
- Marina P Gonçalves
- Etienne Aumont
- Joseph Therriault
- Robert Hopewell
- Pedro Rosa‐Neto
- Stijn Servaes
- Paolo Vitali
- Gleb Bezgin
- Kely Monica Quispialaya Socualaya
- Brandon J Hall
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Université du Québec à Montréal (CA)
- University of Pittsburgh (US)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107658
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00