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Topological reorganization of functional hubs in patients with Parkinson's disease with freezing of gait (PD-FOG).The hub regions were significantly reorganized in the PD-FOG participants.The mean degree of each node in the reference group (x-axis) is plotted versus the difference between the mean degree of each node of the reference group and chosen group (y-axis).Hub disruption index ( ) was calculated as the slope of the line (shown in red) fitted to the scatterplot.(A) Reference group: normal controls (NC); chosen group: PD-FOG.(B) Reference group: NC; chosen group: Parkinson's disease with no freezing of gait (PD-nFOG).(C) Reference group: PD-nFOG) = ; chosen group: PD-FOG.The red color denotes increased hubness, on average, in the chosen group compared to the reference group; blue denotes abnormally decreased hubness in the chosen group.The right panel in each of the subfigures is the cortical surface representation of the in mean degree between the reference and chosen group and the colors are the same as in the scatter plot.