Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets
Glucagon/glucagon-like peptide 1 sensitizes glucose-induced microtubule remodeling in β-cells. Microtubule density in islets inversely correlates with the α-cell-to-β-cell ratio. Glucose-stimulated insulin secretion levels in single islets positively correlate with their α-cell-to-β-cell ratio. Glucagon and microtubule destabilization mobilize the same granule pool.
Authors
- SHANNON GIBSON
- David A. Jacobson (ORCID: https://orcid.org/0000-0003-1816-5375)
- Syed Nooruzuha Barmaver (ORCID: https://orcid.org/0000-0002-0025-4647)
- Irina Kaverina (ORCID: https://orcid.org/0000-0002-4002-8599)
- Mahircan Yagan
- Gu Guoqiang
- Ruiying Hu
- Hamida K. Ahmed
- Appakalai N. Balamurugan
Institutions
- University of Louisville (US)
- Vanderbilt University (US)
- Norton Healthcare (US)
Publication Details
- Journal
- Diabetes
- Published
- 2026-01-09
- DOI
- https://doi.org/10.2337/db24-1025
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- Vanderbilt University Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases