Investigation of cortical cholinergic projection integrity in relation to longitudinal cognitive performance in Parkinson's disease
We found strong evidence for a modest association between baseline cortical cholinergic integrity and cognition in PD. This suggests that the composite measure of cortical cholinergic projection integrity used in this analysis was consistently related to cognitive performance across assessment timepoints but there was no evidence baseline integrity predicted differential rates of cognitive decline. Combining measures from additional components of the brain cholinergic system, or from other neurotransmitter systems, may provide greater insight into cognitive trajectories in PD.
Authors
- Tim Anderson (ORCID: https://orcid.org/0000-0002-0191-0204)
- Ian J. Kirk (ORCID: https://orcid.org/0000-0002-0444-6718)
- John C. Dalrymple‐Alford (ORCID: https://orcid.org/0000-0002-6672-033X)
- Nicola M. Slater (ORCID: https://orcid.org/0000-0001-5520-9758)
- Tracy Melzer
- Ross Keenan
- Kyla‐Louise Horne
- Daniel J Myall
- Campbell J Le Heron
- Wassilios G Meissner
Institutions
- Université de Bordeaux (FR)
- University of Auckland (NZ)
- University of Canterbury (NZ)
- Christchurch Hospital (NZ)
- Pacific Radiology (New Zealand) (NZ)
- New Zealand Brain Research Institute (NZ)
- University of Otago (NZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105399
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00