Involvement of synaptophysin and microtubule-associated protein 2 in the neuroprotective effect of berberine in an amyloid β-induced rat model of Alzheimer's disease.
Berberine demonstrated protective effects against amyloid β-induced cognitive deficits in a rat AD model, and these effects were associated with reduced oxidative and nitrosative stress, inflammation, apoptosis, and AChE activity, alongside enhanced synaptic protection.
Authors
- Saeid Iranzadeh
- Mehrdad Roghani
- Siamak Afshinmajd
- Mohammad-Hadi Akbarizadeh-Mashkani
Institutions
- Shahed University (IR)
- Iran University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2026-01-09
- DOI
- https://doi.org/10.22038/ajp.2025.26026
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shahed University