The Effect of GLP-1 Receptor Agonists on Alanine Aminotransferase and Other Metabolic Parameters in Youths with Obesity: A Systematic Review and Meta-Analysis
Our meta-analysis suggests GLP-1 RAs improve BMI and show a modest decrease in ALT levels in youths with obesity. The clinical significance of the ALT decreases remains uncertain and warrants further examination in future trials.
Authors
- Robert Siegel (ORCID: https://orcid.org/0000-0002-0249-6041)
- Kristin Stackpole (ORCID: https://orcid.org/0000-0003-0917-2354)
- Roohi Y. Kharofa (ORCID: https://orcid.org/0000-0002-3923-2779)
- Lauren Hertzer
- E. Melinda Mahabee-Gittens
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Childhood Obesity
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1177/21532176251413898
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00