MR‐visible perivascular space burden associated with concurrent cognition and post‐mortem assessment of cerebrovascular disease
In vivo MRI-visible PVS burden within the subcortical WM is associated with a cognitive profile and neuropathologic findings consistent with cerebrovascular disease, supporting its use as a vascular marker in aging studies. Future work should consider longitudinal analysis to confirm the temporal order of increases in MR-visible PVS burden and cognitive decline.
Authors
- David Lahna (ORCID: https://orcid.org/0000-0002-8113-825X)
- Nora Mattek (ORCID: https://orcid.org/0000-0003-2623-1969)
- D. A. Schwartz (ORCID: https://orcid.org/0000-0001-8252-4753)
- Justin Hurworth
- Natalie Roese (ORCID: https://orcid.org/0000-0003-4376-9963)
- Randy L Woltjer
- Lisa C Silbert
Institutions
- Oregon Health & Science University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Advanced Imaging Research (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107686
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00