The utility of plasma <i>p</i> ‐tau217 in former American football players at risk for chronic traumatic encephalopathy

Plasma p-tau217 has usefulness in quantifying Aβ pathology but restricted utility for detection of CTE. In this at-risk for CTE sample, p-tau217 and Aβ-PET were associated at the group level. At the individual level, false Aβ-positives (and negatives) existed, including Aβ- participants with high p-tau217. We will explore whether this discrepancy is due to disease or peripheral interference with the N-terminal binding in p-tau assays.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105546
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The utility of plasma p ‐tau217 in former American football players at risk for chronic traumatic encephalopathy

K. Blennow, Annalise E. Miner, Robert C. Cantu, Jennifer V. Wethe et al.
Alzheimer s & Dementia
Traumatic Brain Injury Research
article

The utility of plasma p ‐tau217 in former American football players at risk for chronic traumatic encephalopathy

K. Blennow, Annalise E. Miner, Robert C. Cantu, Jennifer V. Wethe, Laura Joan Balcer, Charles Bernick, Reiman Em, Jeremy Tanner, J. R. Cummings, Jenna R. Groh, Charles Adler, Ann C. McKee, Thor D. Stein, Michael L Alosco, Breton M. Asken, Joseph N. Palmisano, Henrik Zetterberg, David W. Dodick, Yorghos Tripodis, William B. Barr, Robert A. Stern, Brett Martin, Jesse Mez, Nicholas J. Ashton, Sarah J Banks, Gil D. Rabinovici
article en

Abstract

Plasma p-tau217 has usefulness in quantifying Aβ pathology but restricted utility for detection of CTE. In this at-risk for CTE sample, p-tau217 and Aβ-PET were associated at the group level. At the individual level, false Aβ-positives (and negatives) existed, including Aβ- participants with high p-tau217. We will explore whether this discrepancy is due to disease or peripheral interference with the N-terminal binding in p-tau assays.

Alzheimer s & DementiaVol. 21(S2)
Boston University (US), University of Science and Technology of China (CN), Brigham and Women's Hospital (US), Cleveland Clinic (US), University of Nevada, Las Vegas (US), University of Wisconsin–Madison (US), University of Arizona (US), The University of Texas at San Antonio Health Science Center (US), University of Phoenix (US), University of California, San Francisco (US), University of Washington (US), Lou Ruvo Brain Institute (US), University of Florida Health (US), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), University of California System (US), University of California San Diego (US), Sorbonne Université (FR), VA Puget Sound Health Care System (US), University Memory and Aging Center (US), Alzheimer’s Disease Neuroimaging Initiative (US), Institut de Myologie (FR), Pitié-Salpêtrière Hospital (FR), Mayo Clinic in Arizona (US), National Hospital for Neurology and Neurosurgery (GB), Institut du Cerveau (FR), Banner Alzheimer’s Institute, University College London (GB), The University of Texas at San Antonio (US), Arizona State University (US), New York University (US), University of Gothenburg (SE)
Openalex Percentile: Top 28%
Traumatic Brain Injury Research
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