At home monitoring of chronic adaptive deep brain stimulation for Parkinson's disease
Exaggerated subthalamic nucleus (STN) beta oscillations and synchrony reflect pathological neural activity in Parkinson's disease (PD) and are associated with worsening of motor symptoms [1]. STN open-loop, continuous deep brain stimulation (cDBS) effectively alleviates motor symptoms but does not respond to dynamic fluctuations in pathological neural activity over time. Recent advancements in DBS systems have enabled local field potentials sensing and tracking of relevant neural biomarkers. Embedded control policy algorithms use these to adjust stimulation parameters in real time, known as adaptive deep brain stimulation (aDBS).
Authors
- Jin Woo Choi (ORCID: https://orcid.org/0000-0002-7290-0361)
- A Negi (ORCID: https://orcid.org/0000-0002-4216-8317)
- Kevin B. Wilkins (ORCID: https://orcid.org/0000-0001-5907-4029)
- Chuyi Cui (ORCID: https://orcid.org/0000-0002-0437-323X)
- Shreesh Karjagi (ORCID: https://orcid.org/0009-0000-5793-8022)
- Helen M. Bronte-Stewart
Institutions
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.brs.2026.103028
- Citations
- 1
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- National Institute of Neurological Disorders and Stroke