Platelets count, platelets indices, fibrinogen, and D-dimer levels among Sudanese women with recurrent pregnancy loss

Objective Recurrent pregnancy loss is a critical health problem, referring to the loss of three or more consecutive pregnancies due to multifactorial reasons. It is associated with evidence of thrombotic tendencies and inflammatory processes. Patients and methods A case–control study included 102 participants: 51 Sudanese women with recurrent pregnancy loss and 51 normal pregnant women serving as age and gestational age-matched controls. Blood analyzer (Sysmex XP-300TM) was used to measure platelet count and platelet indices. The Claus clotting time method was implemented for the determination of plasma fibrinogen levels, and D-dimer levels were estimated with an I-Chroma device. Results A significant decrease in the means of platelet, plateletcrit (PCT), and fibrinogen ( P <0.05), and a notable increase in the means of mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and D-dimer ( P <0.05) when compared with the control group. Statistically insignificant positive correlation between age group and platelet count, MPV, PDW, PCT, P-LCR, fibrinogen, and D-dimer. Similarly, a weak, insignificant positive correlation was found between gestational weeks and platelet count, PDW, PCT, P-LCR, and fibrinogen, while MPV and D-dimer showed a negative, insignificant correlation with gestational weeks. A strong, statistically significant positive correlation was found between platelet count and PCT ( r =0.79, P =0.000), whereas an insignificant correlation was observed between platelet count and MPV ( r =−0.25, P =0.077). Conclusion A significant decrease in the mean platelet count, PCT, and fibrinogen levels, whereas the mean MPV, PDW, P-LCR, and D-dimer levels show a significant increase.