Peripheral Immune Composition in Alzheimer's Disease: Insights from Multi‐Ancestry RNA‐Sequencing and Cell Deconvolution
This study reveals ancestry-specific immune dysregulation in AD, emphasizing the role of monocytes and mast cells in disease pathology. The identification of HRH4-expressing mast cells suggests potential novel inflammatory pathways in AD. These findings highlight varying immune system responses to AD, which may point to different underlying disease processes.
Authors
- Tianjie Gu
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Yousef Mustafa (ORCID: https://orcid.org/0000-0002-5935-7069)
- Concepcion Silva‐Vergara
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Weston Bush
- Mario Cornejo‐Olivas
- Lissette Gomez
- Margaret Pericak‐Vance
- Jonathan L Haines
- Larry D Adams
- Goldie S Byrd
Institutions
- University of Miami (US)
- Universidad Peruana Cayetano Heredia (PE)
- Central University of the Caribbean (PR)
- Universidad Científica del Sur (PE)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107423
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00