Brivaracetam Use in Managing Seizures Following Traumatic Brain Injury

BRV and LEV demonstrated comparable efficacy in preventing post-traumatic seizures in TBI patients. However, seizure incidence did not differ significantly in this sample. Although the study was underpowered for this outcome, BRV was associated with superior neurobehavioral outcomes, particularly during the early recovery period. These findings suggest that BRV may offer a more favorable tolerability profile for seizure prophylaxis following TBI. Larger multicenter studies are warranted to validate these results.