Magnetic resonance molecular imaging of neuroinflammation in mouse models of Alzheimer's and Parkinson's diseases by precision targeting of CSF1‐R
Results demonstrate precision delivery of Caflanone labeled liposomes bearing an MRI diagnostic payload to activated microglia in three different mouse models of neurodegenerative disorders. These nanoparticles can also deliver a therapeutic payload with similar precision, opening a new frontier for the development of both diagnostics and therapeutics for neuroinflammation.
Authors
- Ngeh J. Toyang (ORCID: https://orcid.org/0000-0001-9683-6192)
- Eric A. Tanifum (ORCID: https://orcid.org/0000-0001-8803-5643)
- Andrew Badachhape (ORCID: https://orcid.org/0000-0002-5857-9495)
- Xianwei Sun
- Jeannie Chin (ORCID: https://orcid.org/0000-0001-9902-3744)
- Ananth Annapragada (ORCID: https://orcid.org/0000-0002-3156-9617)
- Terry‐Elinor Reid
- Henry Lowe
- Joshua M Shulman
Institutions
- Concordia University (US)
- Baylor College of Medicine (US)
- 490 BioTech (United States) (US)
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107465
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00