Application of High-Throughput Sequencing Technology in Fetal Growth Restriction and Analysis of Pregnancy Outcomes

Compared with traditional karyotype analysis (3.8% detection rate), high-throughput sequencing technologies (CNV-seq and Trio-WES) significantly improve the detection rate of genetic abnormalities in FGR fetuses to 13.6%. The "karyotype analysis + CNV-seq + Trio-WES" stepwise detection protocol provides critical support for prenatal genetic counseling and clinical decision-making,and contributes to optimizing pregnancy management and outcomes.