Quality of Life, Cost Effectiveness, and Cost Utility Analysis of Activated Clotting Time Guided Heparinisation vs. a Single Bolus of Heparin in Open Abdominal Aortic Aneurysm Repair
In the Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair trial, which was terminated early owing to futility, ACT guided heparinisation did not improve patient outcomes and resulted in a lower QoL at 6 months, along with negative cost utility.
Authors
- Malou van den Boogaard (ORCID: https://orcid.org/0000-0002-1954-7060)
- R.H. Kropman
- Cornelis MA Bruijninckx
- R.J. Hissink
- Mark J.W. Koelemay
- Hoencamp Rigo
- Tjeerd van der Ploeg (ORCID: https://orcid.org/0000-0003-0429-6753)
- M.E. Pierie (ORCID: https://orcid.org/0000-0002-3690-3426)
- Jan D. Blankensteijn (ORCID: https://orcid.org/0000-0002-2062-8749)
- E. Tournoij
- Max Hoebink (ORCID: https://orcid.org/0000-0001-5059-0107)
- Joep A.W. Teijink (ORCID: https://orcid.org/0000-0001-7927-6904)
- H.C.J.L. Buscher
- B.L. Reichmann
- P.M. Schlejen
- Arno M. Wiersema (ORCID: https://orcid.org/0000-0001-6045-9022)
- E.M. Willigendael (ORCID: https://orcid.org/0000-0002-1957-8641)
- Liliane C. Roosendaal (ORCID: https://orcid.org/0000-0002-2667-2054)
- Petr Symerský
- Vos Ja
- De Borst Gj
- Susan Lemson
- Bram Fioole
- Vincent Jongkind
- Jan G.P. Tijssen
- Robert H. Geelkerken
- Michel M.P.J. Reijnen
- Thomas A.H. Steunenberg
- Susan van Dieren
- Jan van Schaik
- Markus G. Steinbauer
- Clark J. Zeebregts
- Denise P. Veelo
- Frank H. Bosch
- Sebastian Debus
- Daniel Eefting
Institutions
- Reinier de Graaf Hospital (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Vascular and Endovascular Surgery
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.ejvs.2026.01.009
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00