Longitudinal Sex Differences in Excitation–Inhibition Balance in Alzheimer's Disease Risk: A Multimodal Neuroimaging Study
These findings provide longitudinal support for a heightened susceptibility to hyperexcitation in female APOE-ε4 carriers, underscoring the importance of sex and genetic risk in preventive and therapeutic strategies for AD. Our multimodal approach integrating structural and functional network data highlights E/I balance as a promising biomarker and treatment target, with levetiracetam representing one potential intervention. Larger studies are needed to confirm how sex- and genotype-specific E/I dysregulation influences dementia risk and therapeutic efficacy.
Authors
- Alexander P. Demos (ORCID: https://orcid.org/0000-0001-7964-7808)
- Igor Fortel (ORCID: https://orcid.org/0000-0001-8084-4403)
- Orly Lazarov
- Liang Zhan
- Andrew P Burns
- Barbara B. Bendlin
- Alex Leow
- Scott R. Mackin
Institutions
- San Francisco VA Medical Center (US)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107724
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00