Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)

We introduced AddiPath, a method for disentangling the contributions of additional pathology from primary pathology. AddiPath uncovered changes in CT not explained by tau deposition in the limbic lobe, possibly indicating TDP-43 deposition. This approach could improve patient selection for clinical trials and treatment stratification. Future work will replicate this finding across additional cohorts and test the applicability of AddiPath to other biomarkers.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105447
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)

Lawrence P. Binding, NP Oxtoby, Isaac Llorente Saguer, Mihaela Croitor et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)

Lawrence P. Binding, NP Oxtoby, Isaac Llorente Saguer, Mihaela Croitor, Christopher S Parker, Daniel C Alexander, Alexandra L Young
article en

Abstract

We introduced AddiPath, a method for disentangling the contributions of additional pathology from primary pathology. AddiPath uncovered changes in CT not explained by tau deposition in the limbic lobe, possibly indicating TDP-43 deposition. This approach could improve patient selection for clinical trials and treatment stratification. Future work will replicate this finding across additional cohorts and test the applicability of AddiPath to other biomarkers.

Alzheimer s & DementiaVol. 21(S2)
The London College (GB), University College London (GB)
Openalex Percentile: Top 28%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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