Work-related physical strain as novel risk factor for the severity of joint inflammation at diagnosis of anti-citrullinated protein antibodies–positive rheumatoid arthritis
Physical strain is a risk factor for more severe joint inflammation at diagnosis in ACPA-positive, but not in ACPA-negative RA. This differential risk factor aggravating joint inflammation adds to the growing evidence of pathophysiological differences between the two RA entities.
Authors
- H.W. van Steenbergen (ORCID: https://orcid.org/0000-0002-3251-0238)
- Dennis A Ton (ORCID: https://orcid.org/0009-0005-6909-8274)
- Bastiaan T van Dijk
- Annette H M van der Helm—van Mil
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/rheumatology/keag009
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Dutch Arthritis Association