Detecting Hippocampal Subfield Iron in Alzheimer's Disease using Ultra‐high Resolution <i>in vivo</i> 7T MRI
We found elevated iron in the subiculum-CA1 hippocampal subregions in vivo in MCI and AD using 7T MRI, correlating with degraded memory performance. Our noninvasive visualization of microscopic hippocampal iron deposition utilizing ultra-high resolution 7T MRI in vivo corroborates post-mortem data. This translational finding could serve as a novel neuroimaging biomarker for iron-based AD pathology and inflammation.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Hangwei Zhuang
- Julian Maclaren (ORCID: https://orcid.org/0000-0001-7073-2926)
- Brian S. Rutt
- Phillip DiGiacomo (ORCID: https://orcid.org/0000-0002-2441-4086)
- Hossein Moein Taghavi (ORCID: https://orcid.org/0000-0002-8585-1634)
- M. L. Bell
- Reese A. Dunne
- Marios Georgiadis
- Mackenzie L. Carlson
- Elizabeth C. Mormino
- Pascal Spincemaille
- Victor W. Henderson
- Yi Wang
Institutions
- Cornell University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106116
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00