Biomarker‐Driven Patterns of Hippocampal Subfield Atrophy in Amnestic Mild Cognitive Impairment

This study reveals distinct patterns of hippocampal subfield atrophy in amnestic MCI, according to amyloid-beta (A) and phosphorylated tau (T) biomarker profiles. The A-T+ group exhibited a unique pattern of subfield vulnerability, primarily affecting the subiculum, suggesting that tau pathology alone may target specific regions of the hippocampus. In contrast, the A+T+ group showed widespread atrophy across multiple subfields, indicating that combined amyloid and tau pathology leads to more extensive hippocampal degeneration. These findings highlight the potential of subfield-specific atrophy patterns as sensitive biomarkers for differentiating early AD stages and tracking disease progression. Future studies should investigate how these patterns correlate with cognitive decline and their predictive value for dementia conversion.