Sex‐specific associations between age‐related blood proteins, cognition, and Alzheimer's biomarkers
Sex modulates the relationship between age-related blood factors, and chronological age, cognition, and AD-related biomarkers. α-Klotho was linked to lower AD pathology only in men, while CCL11 was associated with worse executive function in women. These findings highlight sex-specific biological pathways in aging and neurodegeneration.
Authors
- Irene Navalpotro
- Paula Ortiz‐Romero (ORCID: https://orcid.org/0000-0002-6378-6763)
- Federica Anastasi (ORCID: https://orcid.org/0000-0002-9304-5421)
- Luis Felipe Hernández‐Villamizar
- Rosa María Manero-Borràs
- Helena Blasco‐Forniés
- Oriol Grau‐Rivera
- Marta del Campo
- Albert Puig‐Pijoan
- Luisa Sophie Braun‐Wohlfahrt
- Marina De Diego‐Osaba
- José Contador
- Marc Suarez‐Calvet
- Esther Jiménez‐Moyano
- Isabel Estragués‐Gázquez
- Greta Garcia‐Escobar
- Aida Fernández‐Lebrero
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centre for Genomic Regulation (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107568
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00