KNTC1 and PRC1 define an immunosuppressive microenvironment and poor prognosis in liposarcoma

We constructed a robust two-gene prognostic model that effectively predicts survival, reflects tumor immune microenvironment heterogeneity, and distinguishes pathological subtypes in LPS. Our findings provided valuable insights for prognostic stratification and personalized treatment strategies.

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Publication Details

Journal
European journal of medical research
Published
2026-01-09
DOI
https://doi.org/10.1186/s40001-025-03703-z
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
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article

KNTC1 and PRC1 define an immunosuppressive microenvironment and poor prognosis in liposarcoma

Minjie Zhang, Xiangjie Fang, Zihan Yang, Yanpin Ma et al.
European journal of medical research
Sarcoma Diagnosis and Treatment
article

KNTC1 and PRC1 define an immunosuppressive microenvironment and poor prognosis in liposarcoma

Minjie Zhang, Xiangjie Fang, Zihan Yang, Yanpin Ma, Penghui Li, Lele Zhang
article en

Abstract

We constructed a robust two-gene prognostic model that effectively predicts survival, reflects tumor immune microenvironment heterogeneity, and distinguishes pathological subtypes in LPS. Our findings provided valuable insights for prognostic stratification and personalized treatment strategies.

European journal of medical researchVol. 31(1)
Henan University of Science and Technology (CN), First Affiliated Hospital of Xinxiang Medical University (CN), First Affiliated Hospital of Henan University of Science and Technology (CN)
No poverty
Openalex Percentile: Top 93%
Sarcoma Diagnosis and Treatment
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