An atypical presentation of autopsy confirmed rapidly progressive early onset Alzheimer's disease with borderline CSF biomarkers: A case study

This case illustrates an atypical, rapidly progressive clinical presentation of autopsy-confirmed AD with CSF biomarkers for AD in the "borderline" range relatively close to death. In clinical practice, cases where biomarkers are "borderline" are not uncommon and pose challenges to differentiating between dementias due to different underlying neurodegenerative diseases. Learning from atypical presentations such as this one may augment diagnostic accuracy and clinical disease management. Further research is needed to establish correspondence of "borderline" or "indeterminate" CSF biomarkers to neuropathological findings seen at autopsy.