Microvascular Resistance Reserve vs Coronary Flow Reserve to Assess Age-Related Trends in Coronary Microvascular Dysfunction

Structural CMD increases with age regardless of obstructive CAD, while functional CMD prevalence increases only in nonobstructive CAD. CFR may overestimate CMD in epicardial disease, whereas MRR provides a more consistent assessment regardless of obstructive CAD, underscoring the need for prospective studies on their clinical relevance.

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Publication Details

Journal
JACC: Cardiovascular Interventions
Published
2026-01-09
DOI
https://doi.org/10.1016/j.jcin.2025.11.019
Citations
1
Primary Topic
Cardiac Imaging and Diagnostics
Type
article
Field-Weighted Citation Impact
31.92
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article

Microvascular Resistance Reserve vs Coronary Flow Reserve to Assess Age-Related Trends in Coronary Microvascular Dysfunction

Maribel Madera‐Cambero, Paul Knaapen, René van Es, Mauro Echavarría-Pinto et al.
1 citations
JACC: Cardiovascular Interventions
Cardiac Imaging and Diagnostics
31.92
article

Microvascular Resistance Reserve vs Coronary Flow Reserve to Assess Age-Related Trends in Coronary Microvascular Dysfunction

Maribel Madera‐Cambero, Paul Knaapen, René van Es, Mauro Echavarría-Pinto, Koen Marques, Hernán Mejía‐Rentería, Coen K.M. Boerhout, Rupak K. Banerjee, Eun‐Seok Shin, Ji Hyun Jung, Nobuhiro Tanaka, Tadashi Murai, Tim P. van de Hoef, Joon-Hyung Doh, Mohamed A. Effat, Bon-Kwon Koo, Hitoshi Matsuo, Ashkan Eftekhari, Peter Damman, Masafumi Nakayama, Pim van der Harst, Jan J. Piek, Giampaolo Niccoli, Joo Myung Lee, Masahiro Hoshino, Javier Escaned, Martijn Meuwissen, Hanae F. Namba, Guus A. de Waard, Timo Nijkamp, Chang-Wook Nam, Evald H. Christiansen, Tsunekazu Kakuta, Niels van Royen
article en
1 citations

Abstract

Structural CMD increases with age regardless of obstructive CAD, while functional CMD prevalence increases only in nonobstructive CAD. CFR may overestimate CMD in epicardial disease, whereas MRR provides a more consistent assessment regardless of obstructive CAD, underscoring the need for prospective studies on their clinical relevance.

JACC: Cardiovascular InterventionsVol. 19(4)
Twitter (United States) (US), Universidad Complutense de Madrid (ES), University of Parma (IT), Radboud University Nijmegen (NL), Autonomous University of Queretaro (MX), Samsung Medical Center (KR), Aarhus University Hospital (DK), Seoul National University Hospital (KR), Radboud University Medical Center (NL), Hospital Clínico San Carlos (ES), University Medical Center Utrecht (NL), Tsuchiura Kyodo General Hospital (JP), Tokyo Medical University Hachioji Medical Center (JP), Netherlands Heart Institute (NL), Amphia Ziekenhuis (NL), Inje University Ilsan Paik Hospital (KR), Keimyung University Dongsan Medical Center (KR), Sejong General Hospital (KR), Ulsan University Hospital (KR), Cincinnati VA Medical Center (US), Tergooi (NL), Amsterdam University Medical Centers (NL), Gifu Heart Center (JP), Keimyung University (KR), University of Cincinnati (US), Sungkyunkwan University (KR)
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Cardiac Imaging and Diagnostics
31.92
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