Switch to Bictegravir/Tenofovir Alafenamide/Emtrictabine or Dolutegravir + Tenofovir Disoproxil Fumarate/Emtrictabine in Virologically Suppressed People With Human Immunodeficiency Virus: Outcomes in Real-world Setting With and Without Tenofovir Resi

in a real-world setting, switching to BIC/TAF/FTC or DTG + TDF/FTC in PWH with virological success was associated with a non-significant risk of VF, but M184V or M184I mutations and tenofovir resistance had no effect on VF. Most VF were blips or related to unmeasured adherence issues.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2025-12-25
DOI
https://doi.org/10.1093/cid/ciaf726
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Switch to Bictegravir/Tenofovir Alafenamide/Emtrictabine or Dolutegravir + Tenofovir Disoproxil Fumarate/Emtrictabine in Virologically Suppressed People With Human Immunodeficiency Virus: Outcomes in Real-world Setting With and Without Tenofovir Resi

Romain Palich, J.M. Chapplain, M.A. Trabaud, Laurent Hocqueloux et al.
Clinical Infectious Diseases
HIV/AIDS drug development and treatment
article

Switch to Bictegravir/Tenofovir Alafenamide/Emtrictabine or Dolutegravir + Tenofovir Disoproxil Fumarate/Emtrictabine in Virologically Suppressed People With Human Immunodeficiency Virus: Outcomes in Real-world Setting With and Without Tenofovir Resi

Romain Palich, J.M. Chapplain, M.A. Trabaud, Laurent Hocqueloux, Alain Makinson, François Raffi, M.J. Ducassou, L Pépin-Puget, K Bouiller, C De La Porte Des Vaux, N Mrozek, S Sunder, L de Ghellinck, F Bozon, C Chirouze, C Bernard-Henry, Agathe Becker, M Carles, J Lagoutte, R Mahot, L Quaesaet, E Cua, Anne Maillard, S Benkouiten, N Qatib, V Corbin, A Sève, M De La Chapelle, Q Lepiller, P Gantner, C Jacomet, M Valette, M Dupont, S Marty-Quinternet, S Jaffuel, D. Lebrun, L Hustache-Mathieu, C Lebreton, C Loraux, V Icard, L Fagour, N Tissot, A Benelhadj, David Rey, P Gazeau, M Digumber, S Rezig, C Richaud, F Anglade, the Dat’AIDS Study Group, B Lefèvre, S Le Gac, M Tetart, AS Brunel, Djelloul A Zaghdoudi, J Izard, H Durox, F Boulard, Claudine Duvivier, S Ansart, Y Quintric, A Brebion, L Bohard, L Vitry d’Aubigny, M. C. VIDAL, M Sebillotte, C Lahuna, B Rosolen, M Gousseff, C Theis, S Sahyouni, A Pouvaret, M Thierry
article en

Abstract

in a real-world setting, switching to BIC/TAF/FTC or DTG + TDF/FTC in PWH with virological success was associated with a non-significant risk of VF, but M184V or M184I mutations and tenofovir resistance had no effect on VF. Most VF were blips or related to unmeasured adherence issues.

Clinical Infectious Diseases
Université d'Orléans (FR), Hôpital Necker-Enfants Malades (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Lyon College (US), Université de Montpellier (FR), Centre Hospitalier Universitaire de Nantes (FR), Sorbonne Université (FR), Centre Hospitalier Universitaire de Montpellier (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre Hospitalier Universitaire de Reims (FR), Pitié-Salpêtrière Hospital (FR), Hôpital Pontchaillou (FR), Centre d'Investigation Clinique de Nantes (FR), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Institut Cochin (FR), Centre hospitalier universitaire d'Orléans (FR), Université de Strasbourg (FR), Université de Reims Champagne-Ardenne (FR), Nantes Université (FR)
Good health and well-being
Openalex Percentile: Top 29%
HIV/AIDS drug development and treatment
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