Exploratory Study on Factors Associated with Treatment Outcomes in MRSA Bacteremia

This exploratory retrospective study aimed to investigate factors associated with treatment outcomes in 37 adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We assessed the association of clinical factors, including vancomycin (VCM) exposure area under the curve divided by minimum inhibitory concentration (AUC/MIC) estimated by Bayesian analysis from initial therapeutic drug monitoring and baseline host factors (e.g., serum albumin and Charlson Comorbidity Index [CCI]), with treatment outcomes. Owing to the limited sample size, the statistical power was insufficient to identify independent predictors through multivariate analysis. Baseline serum albumin showed a notable, albeit non-significant, trend toward an association with treatment failure. However, this finding should be interpreted with caution owing to potential confounding by factors, such as high CCI scores and malignancy. In conclusion, this study could not identify independent predictors for MRSA bacteremia, suggesting that a complex interplay of multiple factors influences treatment outcomes. Larger, prospective studies are required to construct a comprehensive predictive model.