Sleep spindles and slow oscillations predict neurofilament‐light, neurogranin 36, Chitinase‐3‐like protein‐1 and cognition in mild to moderate Alzheimer's Disease

Our novel findings demonstrate that spindle and SO activity are associated with NfL, YKl-40, and NG-36, and cognitive decline, constituting predictive, non-invasive biomarkers of neurodegeneration, cognition, and mental health in AD. They may thus provide novel treatment targets for delaying AD progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_107617
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Sleep spindles and slow oscillations predict neurofilament‐light, neurogranin 36, Chitinase‐3‐like protein‐1 and cognition in mild to moderate Alzheimer's Disease

Barbé Ferran, Shahla Bakian Dogaheh, Anna Carnes, Farida Dakterzada et al.
Alzheimer s & Dementia
Sleep and Wakefulness Research
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Sleep spindles and slow oscillations predict neurofilament‐light, neurogranin 36, Chitinase‐3‐like protein‐1 and cognition in mild to moderate Alzheimer's Disease

Barbé Ferran, Shahla Bakian Dogaheh, Anna Carnes, Farida Dakterzada, Arsenio Paez, Sam O Gillman, Thien Thanh Dang‐Vu, Gerard Piñol‐Ripoll
article en

Abstract

Our novel findings demonstrate that spindle and SO activity are associated with NfL, YKl-40, and NG-36, and cognitive decline, constituting predictive, non-invasive biomarkers of neurodegeneration, cognition, and mental health in AD. They may thus provide novel treatment targets for delaying AD progression.

Alzheimer s & DementiaVol. 21(S2)
University of Oxford (GB), Hospital Universitari de Santa Maria (ES), Institut Universitaire de Gériatrie de Montréal (CA), Instituto de Investigación Biomédica de Lleida (ES), Concordia University (CA)
Openalex Percentile: Top 29%
Sleep and Wakefulness Research
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