Recurrent penile and oral aphthosis revealing a large granular T-cell lymphoproliferative disorder
Large granular T-cell lymphoproliferative disorders are rare and often silent, making diagnosis difficult. A 26-year-old man had recurrent oral and genital aphthous ulcers, which were initially diagnosed as idiopathic bipolar aphthosis. Colchicine therapy induced neutropenia, prompting investigations that revealed a clonal large granular T-cell lymphoproliferative disorder. This case underscores the importance of considering haematological disease when recurrent mucosal aphthosis is associated with unexplained neutropenia.
Authors
- T. Mahévas (ORCID: https://orcid.org/0000-0001-5951-1831)
- Estelle Charvet (ORCID: https://orcid.org/0000-0003-1841-3471)
- Marie Jachiet (ORCID: https://orcid.org/0000-0001-9650-5000)
- S. Fouéré (ORCID: https://orcid.org/0000-0002-9734-7451)
- David Boutboul
- Arno Wahler
- Jean-Noël Dauendorffer
- Jean-David Bouazi
Institutions
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Biologie Paris-Seine (FR)
- Hôpital Saint-Louis (FR)
- Université Paris 1 Panthéon-Sorbonne (FR)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1093/ced/llag016
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00