Association of blood‐based DNA methylation measures of biological aging with cognitive decline and hippocampal atrophy
Older blood-based DNAm age is associated with increased rate of cognitive decline and hippocampal atrophy. Mechanistic studies are required to elucidate the pathobiological underpinnings of DNAm aging with cognitive outcomes.
Authors
- R. Dorajoo
- Andrea Britta Maier (ORCID: https://orcid.org/0000-0001-7206-1724)
- Sim Mk
- Yuan Cai (ORCID: https://orcid.org/0000-0002-7551-2866)
- Jian Hua Tay (ORCID: https://orcid.org/0009-0004-4399-7215)
- Christopher Chen
Institutions
- Agency for Science, Technology and Research (SG)
- The Royal Melbourne Hospital (AU)
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- National University Hospital (SG)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105492
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00