PET/CT Evaluation of Brain Aβ and Metabolism in a Marmoset Model of Alzheimer's Disease Based on Tau Seeding
We established, characterized, and validated a marmoset model of sporadic AD based on seeding tau to accelerate the emergence of AD-related phenotypes. These marmosets will be invaluable in translational research to elucidate the pathogenic mechanisms of AD and contribute to novel therapeutics for AD.
Authors
- Yongshan Mou
- Thais Rafael Guimarães (ORCID: https://orcid.org/0000-0001-8324-0269)
- Seung‐Kwon Ha
- B. Zhang
- Leila Letica
- David J. Schaeffer (ORCID: https://orcid.org/0000-0003-2201-7092)
- Y. Choi
- Lauren A. Bailey
- Afonso C Silva
- Ryan Robert Dyer
- Stacey J Sukoff Rizzo
- Lauren K Hayrynen Schaeffer
- Emily S. Rothwell
- Jung Eun Park
- Diego Szczupak
- Amantha Thathiah
- Lauren R Dubberley
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107737
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00