Ruxolitinib Suppresses Interferon‐γ‐Induced JAK/STAT Activation in Oral Keratinocytes
IFN-γ induces robust and sustained activation of STAT1 and upregulation of HLA-DRB1 in oral keratinocytes, both effectively suppressed by ruxolitinib. These findings underscore the therapeutic potential of targeting the JAK/STAT pathway in oral inflammatory diseases.
Authors
- Henrik Dommisch (ORCID: https://orcid.org/0000-0003-1043-2651)
- Kerstin Danker (ORCID: https://orcid.org/0000-0002-7214-4682)
- Kim Natalie Stolte (ORCID: https://orcid.org/0000-0003-0756-0310)
- Anna Fedorova
- Sameh Attia
Institutions
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Clinical and Experimental Dental Research
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1002/cre2.70281
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Berlin Institute of Health