Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles

The analyzed variants in the PTPN22, CD226, and INS genes were overrepresented in pediatric patients with T1D, suggesting potential therapeutic targets for modulating the autoimmune process. Their associations with specific clinical and autoimmune profiles can be applied in the identification of high-risk patients and help optimize their follow-up.

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Publication Details

Journal
Anales de Pediatría (English Edition)
Published
2026-01-01
DOI
https://doi.org/10.1016/j.anpede.2025.504063
Primary Topic
Diabetes and associated disorders
Type
article
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article

Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles

Cristobol Barrios, Purificación Ros Pérez, María Encarnación Donoso Navarro, Miriam Díez Blanco et al.
Anales de Pediatría (English Edition)
Diabetes and associated disorders
article

Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles

Cristobol Barrios, Purificación Ros Pérez, María Encarnación Donoso Navarro, Miriam Díez Blanco, Esmeralda Colino Alcol, Nuria Santiesteban Rodríguez, Itziar Martínez-Badás
article en

Abstract

The analyzed variants in the PTPN22, CD226, and INS genes were overrepresented in pediatric patients with T1D, suggesting potential therapeutic targets for modulating the autoimmune process. Their associations with specific clinical and autoimmune profiles can be applied in the identification of high-risk patients and help optimize their follow-up.

Anales de Pediatría (English Edition)Vol. 104(1)
Hospital Universitario Puerta de Hierro Majadahonda (ES), Hospital Infantil Universitario Niño Jesús (ES), Universidad Autónoma de Madrid (ES)
Good health and well-being
Openalex Percentile: Top 93%
Diabetes and associated disorders
DOIOpen Access PDFOpenAlex
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Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles — Cristobol Barrios, Purificación Ros Pérez, et al. · Anales de Pediatría (English Edition) (2026) | TGRS Research Map | TGRS