Urinary Neutrophil Mediators as Predictive Biomarkers for Severe Dengue in Adults

Reliable prognostic biomarkers remain an unmet need in dengue. We evaluated urinary neutrophil gelatinase-associated lipocalin and soluble urokinase plasminogen activator receptor for severe dengue prediction in the febrile phase. Urinary neutrophil gelatinase-associated lipocalin and soluble urokinase plasminogen activator receptor demonstrated areas under the receiver operating curve of 0.88 and 0.79, respectively, in discriminating against severe dengue. The noninvasive sampling offers practical advantages as risk stratification tools.