Refining early tau‐PET staging using CA1 and prosubiculum rather than the whole hippocampus
Limiting hippocampal tau quantification to the CA1 and prosubiculum improved the accuracy of tau quantification. This improvement was due to a reduction in false positives due to choroid plexus off-target binding and an improved sensitivity to CA1-specific tau signal. We recommend adopting this approach to improve the detection of tau pathology using tau-PET.
Authors
- S. Gauthier
- Nesrine Rahmouni
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- J. K. M. ller Stevenson
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Arthur Macedo
- Etienne Aumont
- Joseph Therriault
- Brandon J Hall
- Stijn Servaes
- Gleb Bezgin
- Pedro Rosa‐Neto
Institutions
- Montreal Neurological Institute and Hospital (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107689
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00