Clinical significance of YAP and androgen receptor expression in osteosarcoma: Evidence from a retrospective cohort study

This study investigates the expression of Yes-associated protein (YAP) and androgen receptor (AR) in osteosarcoma and assess their prognostic significance. A retrospective cohort of 100 osteosarcoma patients and 30 adjacent normal tissues was analyzed by immunohistochemistry. Expression levels were correlated with clinicopathological features and progression-free survival. High expression of YAP (65%) and AR (60%) was significantly more frequent in osteosarcoma than in normal tissues. Both markers were associated with advanced stage and distant metastasis, and their co-overexpression predicted the shortest median progression-free survival (9 months). Interaction analysis confirmed a synergistic effect of YAP and AR on poor prognosis. YAP and AR are frequently co-overexpressed in osteosarcoma and jointly contribute to tumor aggressiveness and unfavorable outcomes. Their combined evaluation may serve as a novel prognostic indicator and potential therapeutic target.