Dietary (poly)phenols as modulators of natural killer cell function and immunosenescence: From molecular pathways to clinical evidence

Polyphenols exhibit significant dose- and context-dependent immunomodulatory roles, particularly in enhancing NK cell function and mitigating immunosenescence. While preclinical data are promising, further clinical trials addressing bioavailability challenges and interindividual variability are crucial to translating these findings into effective and personalized dietary and therapeutic strategies for promoting immune health in aging populations.