Unveiling the Temporal Dynamics of White Matter Hyperintensities Related to Alzheimer's Disease in Down Syndrome
WMH decreased more frequently over time in DS compared to the general population, particularly in individuals with symptomatic AD and high baseline WMH volume. This unexpected finding, which cannot be attributed to atrophy, offers novel insights into WMH aetiology in DS and has significant implications for targeted interventions using WMH as an outcome.
Authors
- Lucía Maure‐Blesa
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Olivia Belbin
- Sandra M. Giménez
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Zili Zhao
- Jose Allende Parra
- Bessy Benejam
- Laura Videla
- Aida Sanjuan Hernandez
- Laura Del Hoyo
- Íñigo Rodríguez‐Baz
- Sara E Zsadanyi
- Alberto Lleó
- Susana Fernandez
- Mateus Rozalem Aranha
- Alejandra O. Morcillo‐Nieto
- Lídia Vaqué‐Alcázar
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106414
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00