RAS-variant allele frequency as a potential prognostic marker of overall survival in patients with metastatic colorectal cancer
This is the first real world evidence of the potential prognostic significance of VAF in mCRC. Patients with low RAS VAF had better survival compared with high VAF counterparts. Presence of low RAS VAF in tumour samples may suggest that patients progress in a manner resembling RAS wild-type tumours.
Authors
- Mahtab Farzin
- Tristan Rutland (ORCID: https://orcid.org/0000-0001-7917-5476)
- Stephanie Lim (ORCID: https://orcid.org/0000-0001-5940-7137)
- Tara L. Roberts (ORCID: https://orcid.org/0000-0001-9266-0943)
- Therese M. Becker (ORCID: https://orcid.org/0000-0002-5636-9902)
- Adnan Nagrial (ORCID: https://orcid.org/0000-0003-0275-2479)
- Udit Nindra (ORCID: https://orcid.org/0000-0002-2612-9502)
- Mark Wong
- Jun Hee Hong (ORCID: https://orcid.org/0000-0002-9977-7471)
- Wei Chua
- M. Hong
- Weng Ng
- Lorraine Chantrill
- Ray Asghari
Institutions
- Camden and Campbelltown Hospitals (AU)
- Bankstown Lidcombe Hospital (AU)
- Liverpool Hospital (AU)
- Wollongong Hospital (AU)
- Westmead Hospital (AU)
- Ingham Institute (AU)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.ctarc.2026.101103
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00