Characterizing the relationship between neuroinflammation and neurodegeneration in AD and FTLD
There are distinct inflammatory patterns in AD, PSP, and FTD+/-MND. AD is characterized by increases in inflammatory marker levels, while in PSP the opposite is seen. These differences appear to be related to ptau181-related pathology. Future directions include assessing the contributions of known mediators of neuroinflammation, such as astrocytic reactivity, APOE genotype, and age at onset, to these differences.
Authors
- Anna Vasilevskaya (ORCID: https://orcid.org/0000-0001-7398-9620)
- Chloe Anastassiadis (ORCID: https://orcid.org/0000-0002-0376-0422)
- Susan Helen Fox (ORCID: https://orcid.org/0009-0004-7568-1645)
- Hyman Bt
- Arnold Sm
- Kasey Cortez
- Nico Paulo Dimal
- A. E. Lang
- Pia Kivisäkk
- Martin Ingelsson
- Carmela Tartaglia
- Michelle Tsang
- Blas Couto
- Gabor G. Kovacs
- David F. Tang‐Wai
- Simrika Thapa
Institutions
- Uppsala University (SE)
- University Health Network (CA)
- Harvard University (US)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Massachusetts General Hospital (US)
- Occupational Cancer Research Centre (CA)
- Instituto de Neurología Cognitiva (AR)
- Parkinson's Clinic of Eastern Toronto & Movement Disorders Centre (CA)
- Ontario Brain Institute (CA)
- Krembil Brain Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107533
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00