Intervention‐related changes in variability of dynamic functional connectivity and the relationship to cognition in older adults at risk for Alzheimer's disease
An intervention to enhance physical activity mitigated age-related increases in v-dFC network segregation and connectivity of the DefaultC subnetwork. DefaultC corresponds to the medial temporal lobe subsystem (Andrews-Hanna et al., 2010), including the parahippocampal, retrosplenial and inferior parietal regions, which are highly vulnerable to AD pathology (Buckner et al., 2005).
Authors
- Kayla Williams (ORCID: https://orcid.org/0000-0002-1359-7411)
- Nagashree Thovinakere (ORCID: https://orcid.org/0009-0008-2390-5490)
- Jillian Caplan (ORCID: https://orcid.org/0009-0003-9680-0159)
- Carolynn Boulanger
- Paulina Skolasinska (ORCID: https://orcid.org/0000-0001-7995-9588)
- M. Catherine Bennett (ORCID: https://orcid.org/0000-0001-6178-8610)
- Alfie Wearn (ORCID: https://orcid.org/0000-0001-7699-648X)
- Nicolas Lavoie
- Roni Setton (ORCID: https://orcid.org/0000-0002-8829-364X)
- Ilana R. Leppert (ORCID: https://orcid.org/0000-0001-7672-0918)
- Jacques Piché
- Colleen Hughes
- Shania Fock Ka Bao
- Linda Man-Kuen Li
- Franciska Otaner
- Sofia Ricciardelli
- Garance Barnoin
- Prantik Kundu
- Adrián Noriega de la Colina
- Ryan Kara
- Sarah Elbaz
- Helen Pallett‐Wiesel
- Andreanne Powers
- Maggie Nguyen
- Laurence Côté
- Arthur F. Kramer
- Caitlin S. Walker
- R. Nathan Spreng
- Christine Dery
Institutions
- Northeastern University (US)
- Montreal Neurological Institute and Hospital (CA)
- Allen Institute for Brain Science (US)
- University of Illinois Urbana-Champaign (US)
- University of Toronto (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- Harvard University Press (US)
- Alzheimer Society of Canada (CA)
- Indiana University Bloomington (US)
- McGill Genome Centre (CA)
- Université Laval (CA)
- McGill University (CA)
- Massachusetts Institute of Technology (US)
- Université de Montréal (CA)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105792
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00