Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome

Individuals with 22q11.2 DS present lower iron accumulation in dopaminergic areas, such as substantia nigra, caudate and putamen, relative to healthy controls. These findings suggest a possible association between a dopaminergic dysfunction and abnormal iron accumulation.

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Journal
Frontiers in Psychiatry
Published
2026-01-09
DOI
https://doi.org/10.3389/fpsyt.2025.1652700
Primary Topic
Congenital heart defects research
Type
article
Field-Weighted Citation Impact
0.00

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article

Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome

Juan Pablo Ramírez-Mahaluf, Claudia Ornstein, Daniella Barbagelata, Analía Cuiza et al.
Frontiers in Psychiatry
Congenital heart defects research
article

Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome

Juan Pablo Ramírez-Mahaluf, Claudia Ornstein, Daniella Barbagelata, Analía Cuiza, Marcelo E. Andía, Carlos Milovic, Ángeles Tepper, J. L. Corrales Aguirre, Marisleydis García, María Elisa Maldonado, Cristian Tejos, Javiera Vásquez, Nestor Muñoz
article en

Abstract

Individuals with 22q11.2 DS present lower iron accumulation in dopaminergic areas, such as substantia nigra, caudate and putamen, relative to healthy controls. These findings suggest a possible association between a dopaminergic dysfunction and abnormal iron accumulation.

Frontiers in PsychiatryVol. 16
Universidad de Santiago de Chile (CL), Universidad del Desarrollo (CL), Pontificia Universidad Católica de Chile (CL), Clínica Alemana (CL), Millennium Science Initiative (CL), Hospital Clínico de la Universidad de Chile (CL), Millennium Institute for Integrative Biology (CL)
Institut Català de Nanociència i Nanotecnologia, Agenția Națională pentru Cercetare și Dezvoltare, Agencia Nacional de Investigación y Desarrollo, CHIST-ERA
Good health and well-being
Openalex Percentile: Top 92%
Congenital heart defects research
DOIOpen Access PDFOpenAlex
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Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome — Juan Pablo Ramírez-Mahaluf, Claudia Ornstein, et al. · Frontiers in Psychiatry (2026) | TGRS Research Map | TGRS