Calibration of multi‐site raters for prospective visual read of amyloid PET scans acquired across the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)

Calibration is essential for accurate/reliable amyloid PET visual reads in large multi-center studies with multiple raters. Through the calibration process, we will develop methods to improve the adjudication of borderline/challenging scans and formalize methods for visual reads of amyloid PET tracers that are investigational (i.e., [<sup>11</sup>C]PIB, [<sup>18</sup>F]NAV4694). Involving multiple raters across different sites, who use diverse hardware/software/file format combinations, will mirror the natural heterogeneity present in real-world clinical practice. This calibration set can also serve as a standardized training tool for other studies incorporating amyloid PET visual reads.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_107616
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Calibration of multi‐site raters for prospective visual read of amyloid PET scans acquired across the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)

Michael Zeineh, Jonathan McConathy, Ganna Blazhenets, Bruce E. Hillner et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Calibration of multi‐site raters for prospective visual read of amyloid PET scans acquired across the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)

Michael Zeineh, Jonathan McConathy, Ganna Blazhenets, Bruce E. Hillner, Jeremy Tanner, Carol L. Soppe, Mary Ellen I. Koran, Zoe Lin, Elizabeth C. Mormino, David N. Soleimani‐Meigooni, Sterling C Johnson, Renaud La Joie, Gil D. Rabinovici, Victor L. Villemagne
article en

Abstract

Calibration is essential for accurate/reliable amyloid PET visual reads in large multi-center studies with multiple raters. Through the calibration process, we will develop methods to improve the adjudication of borderline/challenging scans and formalize methods for visual reads of amyloid PET tracers that are investigational (i.e., [<sup>11</sup>C]PIB, [<sup>18</sup>F]NAV4694). Involving multiple raters across different sites, who use diverse hardware/software/file format combinations, will mirror the natural heterogeneity present in real-world clinical practice. This calibration set can also serve as a standardized training tool for other studies incorporating amyloid PET visual reads.

Alzheimer s & DementiaVol. 21(S2)
University of Wisconsin–Madison (US), Lawrence Berkeley National Laboratory (US), The University of Texas at San Antonio Health Science Center (US), University of Pittsburgh (US), University of California, San Francisco (US), University of California System (US), University of Alabama at Birmingham (US), University Memory and Aging Center (US), Institute for Neurodegenerative Disorders (US), Mayo Clinic in Arizona (US), Mayo Clinic Hospital (US), University of Wisconsin Health (US), University of Pennsylvania (US), Stanford University (US)
Openalex Percentile: Top 28%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.