Total plasma cytochrome P450‐soluble epoxide hydrolase oxylipins, apolipoprotein E ε4 carrier status, and white matter hyperintensities in cerebrovascular disease
In individuals with cerebrovascular disease, APOE ε4 carrier status may moderate associations between CYP-sEH oxylipins and WMH volumes. Studies of interventions targeting this pathway should consider stratification based on APOE genotype.
Authors
- A Elang
- Malcolm Binns
- William Z. Lin (ORCID: https://orcid.org/0000-0002-3610-5213)
- Ameer Y. Taha
- Sofia E. Perfetto
- Natasha Z. Anita
- Douglas P. Munoz
- Celine H.L. Huang
- Si Won Ryoo
- Myuri Ruthirakuhan
- Angela C. Roberts
- Sean Symons
- Walter Swardfager
- Alexandra Magliocco
Institutions
- Western University (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Toronto Western Hospital (CA)
- Baycrest Hospital (CA)
- Public Health Ontario (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107679
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00