Sex Hormones Attenuate Pro‐Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell‐Type Specific Manner
Sex hormones such as dihydrotestosterone and estrogen play an important role mediating inflammatory signaling in cells of the IVD, finding which could lead to novel therapeutics for IVD degeneration.
Authors
- Jeffrey L. Hutchinson (ORCID: https://orcid.org/0000-0003-2011-389X)
- Andrew Leung (ORCID: https://orcid.org/0000-0003-3349-1574)
- Cheryle A. Séguin (ORCID: https://orcid.org/0000-0001-6503-9107)
Institutions
- Western University (CA)
Publication Details
- Journal
- JOR Spine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1002/jsp2.70152
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis Society
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada