Characterizing White Matter Hyperintensity Pathology in Alzheimer's Disease Using Multimodal Imaging
This study highlights the interplay of vascular and neurodegenerative pathologies in WMH development in AD, with amyloid burden independently contributing to WMH volume and vascular risk amplifying its effects. Future work will examine spatial WMH distribution across amyloid and vascular risk cohorts to clarify their contributions to WMH development and progression.
Authors
- Ho‐Ching Yang (ORCID: https://orcid.org/0000-0003-2670-1772)
- Tayyebeh Ebrahimi (ORCID: https://orcid.org/0000-0001-6142-3873)
- Kalen Riley (ORCID: https://orcid.org/0000-0003-2005-7007)
- Brian Graner (ORCID: https://orcid.org/0000-0001-8376-1814)
- Yu‐Chien Wu
- Salman Syed Shahid
- Khalid Al‐Ali
- Donna M. Wilcock
- Yomna Takieldeen
- Alzheimer's Disease Neuroimaging Initiative
- Andrew J. Saykin
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107738
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00