Digital Cognitive Markers to Characterize Preclinical Stages of autosomal‐dominant Alzheimer's Disease: A Preliminary Study
TabCAT-BHA detected broader cognitive differences across multiple domains between PSEN1-E280A mutation carriers and non-carriers, underscoring its utility in identifying early cognitive changes during the preclinical stage of AD. Its demonstrated concurrent validity with traditional evaluations further highlights its potential as a scalable, efficient tool for preclinical AD detection, particularly in low- and middle-income countries where resource constraints limit access to traditional diagnostic approaches.
Authors
- D A Rubén Gómez
- Diego Camilo Díaz (ORCID: https://orcid.org/0000-0003-3947-1910)
- Katherine L. Possin (ORCID: https://orcid.org/0000-0002-6623-3793)
- Susana Ramirez (ORCID: https://orcid.org/0000-0001-7774-3644)
- Stella Valencia
- David Fernando Aguillón Niño (ORCID: https://orcid.org/0000-0003-2283-536X)
- Natalia Londono
- Juan Pablo Sanchez
- Natalia Trujillo Orrego
- Sandra P. Trujillo
- Ana Y Baena
Institutions
- University of California, San Francisco (US)
- Florida International University (US)
- Universidad Católica Luis Amigó (CO)
- Universidad de Antioquia (CO)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105619
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00